Names & Taxonomy
- Uniprot ID:
- O95665
- Entry Name:
- NTR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Neurotensin receptor type 2 (NT-R-2) (NTR2) (Levocabastine-sensitive neurotensin receptor)
- Gene Names:
- NTSR2
- Gene Names Primary:
- NTSR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 410
- Sequence:
- METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- Cross Reference Drug Bank:
- DB01106
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled neurotensin receptor activity
G-protein coupled receptor activity
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
regulation of membrane potential
sensory perception - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
regulation of membrane potential
sensory perception - Gene Ontology Molecular Function:
- G-protein coupled neurotensin receptor activity
G-protein coupled receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix