Names & Taxonomy

Uniprot ID:
O95622
Entry Name:
ADCY5_HUMAN
Status:
reviewed
Protein Names:
Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5)
Gene Names:
ADCY5
Gene Names Primary:
ADCY5
Organism:
Homo sapiens (Human)

Structure

Length:
1261
Sequence:
MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).
Catalytic Activity:
ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation:
ENZYME REGULATION: Activated by forskolin (PubMed:24700542). Activated by GNAS. Activity is further increased by interaction with the G-protein beta and gamma subunit complex formed by GNB1 and GNG2 (PubMed:26206488). Is not activated by calmodulin. Inhibited by adenosine and ATP analogs. Inhibited by calcium ions, already at micromolar concentrations (By similarity). Phosphorylation by RAF1 results in its activation (PubMed:15385642).
Gene Ontology Go:
integral component of membrane
intracellular
plasma membrane
primary cilium
adenylate cyclase activity
adenylate cyclase binding
ATP binding
metal ion binding
protein heterodimerization activity
activation of phospholipase C activity
activation of protein kinase A activity
adenosine receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cAMP biosynthetic process
cAMP-mediated signaling
cellular response to forskolin
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
locomotory behavior
neuromuscular process controlling balance
neurotrophin TRK receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of insulin secretion involved in cellular response to glucose stimulus
renal water homeostasis
signal transduction
small molecule metabolic process
synaptic transmission
transmembrane transport
water transport
Gene Ontology Biological Process:
activation of phospholipase C activity
activation of protein kinase A activity
adenosine receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cAMP biosynthetic process
cAMP-mediated signaling
cellular response to forskolin
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
locomotory behavior
neuromuscular process controlling balance
neurotrophin TRK receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of insulin secretion involved in cellular response to glucose stimulus
renal water homeostasis
signal transduction
small molecule metabolic process
synaptic transmission
transmembrane transport
water transport
Gene Ontology Molecular Function:
adenylate cyclase activity
adenylate cyclase binding
ATP binding
metal ion binding
protein heterodimerization activity
Gene Ontology Cellular Component:
integral component of membrane
intracellular
plasma membrane
primary cilium
Keywords:
ATP-binding
Alternative splicing
Cell membrane
Cell projection
Cilium
Complete proteome
Disease mutation
Glycoprotein
Lyase
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Repeat
Transmembrane
Transmembrane helix
cAMP biosynthesis

Publication

PubMed ID:
14702039 16641997 12503609 10481931 15385642 24740569 26206488 22782511 24700542