Names & Taxonomy

Uniprot ID:
O95573
Entry Name:
ACSL3_HUMAN
Status:
reviewed
Protein Names:
Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 3) (LACS 3)
Gene Names:
ACSL3 ACS3 FACL3 LACS3
Gene Names Primary:
ACSL3
Organism:
Homo sapiens (Human)

Structure

Length:
720
Sequence:
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion outer membrane

Function

Function:
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).
Catalytic Activity:
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Cross Reference Drug Bank:
DB00159
Gene Ontology Go:
endoplasmic reticulum
endoplasmic reticulum membrane
Golgi apparatus
integral component of membrane
lipid particle
membrane
mitochondrial outer membrane
perinuclear region of cytoplasm
peroxisomal membrane
ATP binding
long-chain fatty acid-CoA ligase activity
protein domain specific binding
protein kinase binding
brain development
cellular lipid metabolic process
fatty acid biosynthetic process
long-chain fatty acid import
long-chain fatty-acyl-CoA biosynthetic process
positive regulation of Golgi to plasma membrane protein transport
positive regulation of phosphatidylcholine biosynthetic process
positive regulation of secretion
response to nutrient
response to organic cyclic compound
small molecule metabolic process
triglyceride biosynthetic process
very-low-density lipoprotein particle assembly
Gene Ontology Biological Process:
brain development
cellular lipid metabolic process
fatty acid biosynthetic process
long-chain fatty acid import
long-chain fatty-acyl-CoA biosynthetic process
positive regulation of Golgi to plasma membrane protein transport
positive regulation of phosphatidylcholine biosynthetic process
positive regulation of secretion
response to nutrient
response to organic cyclic compound
small molecule metabolic process
triglyceride biosynthetic process
very-low-density lipoprotein particle assembly
Gene Ontology Molecular Function:
ATP binding
long-chain fatty acid-CoA ligase activity
protein domain specific binding
protein kinase binding
Gene Ontology Cellular Component:
endoplasmic reticulum
endoplasmic reticulum membrane
Golgi apparatus
integral component of membrane
lipid particle
membrane
mitochondrial outer membrane
perinuclear region of cytoplasm
peroxisomal membrane
Keywords:
ATP-binding
Complete proteome
Endoplasmic reticulum
Fatty acid metabolism
Ligase
Lipid metabolism
Magnesium
Membrane
Microsome
Mitochondrion
Mitochondrion outer membrane
Nucleotide-binding
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9177793 11707336 15489334 18003621 18691976 21269460 25944712