Names & Taxonomy

Uniprot ID:
O95436
Entry Name:
NPT2B_HUMAN
Status:
reviewed
Protein Names:
Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)
Gene Names:
SLC34A2
Gene Names Primary:
SLC34A2
Organism:
Homo sapiens (Human)

Structure

Length:
690
Sequence:
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.
Gene Ontology Go:
apical plasma membrane
brush border membrane
integral component of membrane
integral component of plasma membrane
plasma membrane
vesicle
phosphate ion binding
sodium ion binding
sodium-dependent phosphate transmembrane transporter activity
sodium:phosphate symporter activity
cellular phosphate ion homeostasis
cellular protein metabolic process
in utero embryonic development
ion transport
phosphate ion transmembrane transport
phosphate ion transport
response to estrogen
sodium ion transmembrane transport
transmembrane transport
Gene Ontology Biological Process:
cellular phosphate ion homeostasis
cellular protein metabolic process
in utero embryonic development
ion transport
phosphate ion transmembrane transport
phosphate ion transport
response to estrogen
sodium ion transmembrane transport
transmembrane transport
Gene Ontology Molecular Function:
phosphate ion binding
sodium:phosphate symporter activity
sodium-dependent phosphate transmembrane transporter activity
sodium ion binding
Gene Ontology Cellular Component:
apical plasma membrane
brush border membrane
integral component of membrane
integral component of plasma membrane
plasma membrane
vesicle
Keywords:
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
10329428 10610722 15815621 15489334 11171583 14702039 12661006 16960801