Names & Taxonomy

Uniprot ID:
O95427
Entry Name:
PIGN_HUMAN
Status:
reviewed
Protein Names:
GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N)
Gene Names:
PIGN MCD4
Gene Names Primary:
PIGN
Organism:
Homo sapiens (Human)

Structure

Length:
931
Sequence:
MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation.
Pathway:
Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
membrane
mannose-ethanolamine phosphotransferase activity
C-terminal protein lipidation
cellular protein metabolic process
GPI anchor biosynthetic process
post-translational protein modification
preassembly of GPI anchor in ER membrane
Gene Ontology Biological Process:
cellular protein metabolic process
C-terminal protein lipidation
GPI anchor biosynthetic process
post-translational protein modification
preassembly of GPI anchor in ER membrane
Gene Ontology Molecular Function:
mannose-ethanolamine phosphotransferase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
membrane
Keywords:
Complete proteome
Disease mutation
Endoplasmic reticulum
Epilepsy
GPI-anchor biosynthesis
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10069808 15489334 17974005 23446422 21493957