Names & Taxonomy
- Uniprot ID:
- O95302
- Entry Name:
- FKBP9_HUMAN
- Status:
- reviewed
- Protein Names:
- Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (Rotamase)
- Gene Names:
- FKBP9 FKBP60 FKBP63
- Gene Names Primary:
- FKBP9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 570
- Sequence:
- MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVKIPPKLAYGNEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVFDIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVLGSGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVAGLPEGYMFIWNGEVSPNLFEEIDKDGNGEVLLEEFSEYIHAQVASGKGKLAPGFDAELIVKNMFTNQDRNGDGKVTAEEFKLKDQEAKHDEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum
Function
- Function:
- PPIases accelerate the folding of proteins during protein synthesis.
- Catalytic Activity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by FK506.
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
calcium ion binding
FK506 binding
peptidyl-prolyl cis-trans isomerase activity
chaperone-mediated protein folding
protein folding
protein peptidyl-prolyl isomerization - Gene Ontology Biological Process:
- chaperone-mediated protein folding
protein folding
protein peptidyl-prolyl isomerization - Gene Ontology Molecular Function:
- calcium ion binding
FK506 binding
peptidyl-prolyl cis-trans isomerase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane - Keywords:
- Alternative splicing
Calcium
Complete proteome
Endoplasmic reticulum
Glycoprotein
Isomerase
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Rotamase
Signal