Names & Taxonomy

Uniprot ID:
O95263
Entry Name:
PDE8B_HUMAN
Status:
reviewed
Protein Names:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein)
Gene Names:
PDE8B PIG22
Gene Names Orf:
PIG22
Gene Names Primary:
PDE8B
Organism:
Homo sapiens (Human)

Structure

Length:
885
Sequence:
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASGPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
Proteomes:
UP000005640

Function

Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
Pathway:
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Catalytic Activity:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
Cofactor:
COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Enzyme Regulation:
ENZYME REGULATION: Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and milrinone as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP.
Active Site:
ACT_SITE 615 615 Proton donor.
Cross Reference Drug Bank:
DB00201 DB00920
Gene Ontology Go:
cytosol
3',5'-cyclic-nucleotide phosphodiesterase activity
metal ion binding
cAMP catabolic process
cyclic nucleotide metabolic process
negative regulation of insulin secretion
signal transduction
Gene Ontology Biological Process:
cAMP catabolic process
cyclic nucleotide metabolic process
negative regulation of insulin secretion
signal transduction
Gene Ontology Molecular Function:
3',5'-cyclic-nucleotide phosphodiesterase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
Keywords:
Alternative splicing
Complete proteome
Cushing syndrome
Disease mutation
Hydrolase
Metal-binding
Phosphoprotein
Reference proteome
cAMP

Publication

PubMed ID:
12372422 12681444 15489334 9784418 17974005 18669648 20085714 20068231 18431404