Names & Taxonomy

Uniprot ID:
O95259
Entry Name:
KCNH1_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Voltage-gated potassium channel subunit Kv10.1)
Gene Names:
KCNH1 EAG EAG1
Gene Names Primary:
KCNH1
Organism:
Homo sapiens (Human)

Structure

Length:
989
Sequence:
MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane
Intramembrane:
INTRAMEM 451 471 Pore-forming; Name=Segment H5.

Function

Function:
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).
Gene Ontology Go:
axolemma
cell surface
dendrite
early endosome membrane
integral component of plasma membrane
neuronal cell body
nuclear inner membrane
perinuclear region of cytoplasm
plasma membrane
presynaptic membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
phosphorelay sensor kinase activity
cellular response to calcium ion
myoblast fusion
potassium ion transmembrane transport
potassium ion transport
regulation of cell proliferation
regulation of membrane potential
startle response
synaptic transmission
Gene Ontology Biological Process:
cellular response to calcium ion
myoblast fusion
potassium ion transmembrane transport
potassium ion transport
regulation of cell proliferation
regulation of membrane potential
startle response
synaptic transmission
Gene Ontology Molecular Function:
delayed rectifier potassium channel activity
phosphorelay sensor kinase activity
Gene Ontology Cellular Component:
axolemma
cell surface
dendrite
early endosome membrane
integral component of plasma membrane
neuronal cell body
nuclear inner membrane
perinuclear region of cytoplasm
plasma membrane
presynaptic membrane
voltage-gated potassium channel complex
Keywords:
Alternative splicing
Calmodulin-binding
Cell membrane
Complete proteome
Disease mutation
Endosome
Epilepsy
Glycoprotein
Ion channel
Ion transport
Membrane
Mental retardation
Nucleus
Phosphoprotein
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel
Interacts With:
P62158; Q7L8L6; P02638; O00560; Q96HA8

Publication

PubMed ID:
9738473 10523298 16710414 15489334 10880439 11943152 21559285 22841712 23144454 22732247 23881642 24587194 25420144 25915598