Names & Taxonomy
- Uniprot ID:
- O95237
- Entry Name:
- LRAT_HUMAN
- Status:
- reviewed
- Protein Names:
- Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase)
- Gene Names:
- LRAT
- Gene Names Primary:
- LRAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 230
- Sequence:
- MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCTGLVSYTTLPAIFIPFFLWMAG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
- Pathway:
- Cofactor metabolism; retinol metabolism.
- Catalytic Activity:
- Phosphatidylcholine + retinol-- = 2-acylglycerophosphocholine + retinyl-ester--.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by all-trans-retinyl alpha-bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK).
- Active Site:
- ACT_SITE 161 161 Acyl-thioester intermediate.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
multivesicular body
perinuclear region of cytoplasm
rough endoplasmic reticulum
phosphatidylcholine-retinol O-acyltransferase activity
retinoic acid binding
retinol binding
transferase activity, transferring acyl groups
fat-soluble vitamin metabolic process
phototransduction, visible light
positive regulation of lipid transport
retinoic acid metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
visual perception
vitamin A metabolic process
vitamin metabolic process - Gene Ontology Biological Process:
- fat-soluble vitamin metabolic process
phototransduction, visible light
positive regulation of lipid transport
retinoic acid metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
visual perception
vitamin A metabolic process
vitamin metabolic process - Gene Ontology Molecular Function:
- phosphatidylcholine-retinol O-acyltransferase activity
retinoic acid binding
retinol binding
transferase activity, transferring acyl groups - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
multivesicular body
perinuclear region of cytoplasm
rough endoplasmic reticulum - Keywords:
- Acyltransferase
Complete proteome
Cytoplasm
Disease mutation
Endoplasmic reticulum
Endosome
Leber congenital amaurosis
Membrane
Polymorphism
Reference proteome
Sensory transduction
Transferase
Transmembrane
Transmembrane helix
Vision