Names & Taxonomy
- Uniprot ID:
- O94910
- Entry Name:
- AGRL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Adhesion G protein-coupled receptor L1 (Calcium-independent alpha-latrotoxin receptor 1) (CIRL-1) (Latrophilin-1) (Lectomedin-2)
- Gene Names:
- ADGRL1 KIAA0821 LEC2 LPHN1
- Gene Names Primary:
- ADGRL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1474
- Sequence:
- MARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLTFPNPYQFISSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPVPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSRNGVVKVVFILYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEEEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAAPGLEGPGPDGDGQMQLVTSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell projection, axon
Function
- Function:
- Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity).
- Gene Ontology Go:
- axon
cell junction
growth cone
integral component of membrane
intracellular
neuron projection
plasma membrane
presynaptic membrane
synapse
carbohydrate binding
cell adhesion molecule binding
G-protein coupled receptor activity
latrotoxin receptor activity
calcium-mediated signaling using intracellular calcium source
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
positive regulation of synapse assembly
positive regulation of synapse maturation
synaptic vesicle exocytosis - Gene Ontology Biological Process:
- calcium-mediated signaling using intracellular calcium source
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
positive regulation of synapse assembly
positive regulation of synapse maturation
synaptic vesicle exocytosis - Gene Ontology Molecular Function:
- carbohydrate binding
cell adhesion molecule binding
G-protein coupled receptor activity
latrotoxin receptor activity - Gene Ontology Cellular Component:
- axon
cell junction
growth cone
integral component of membrane
intracellular
neuron projection
plasma membrane
presynaptic membrane
synapse - Keywords:
- Alternative splicing
Autocatalytic cleavage
Cell junction
Cell membrane
Cell projection
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lectin
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Synapse
Synaptosome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- O00555