Names & Taxonomy

Uniprot ID:
O94906
Entry Name:
PRP6_HUMAN
Status:
reviewed
Protein Names:
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)
Gene Names:
PRPF6 C20orf14
Gene Names Primary:
PRPF6
Organism:
Homo sapiens (Human)

Structure

Length:
941
Sequence:
MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRHGELWCAVSKDIANWQKKIGDILRLVAGRIKNTF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles.

Function

Function:
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Gene Ontology Go:
catalytic step 2 spliceosome
membrane
nuclear speck
nucleoplasm
nucleus
spliceosomal complex
U4/U6 x U5 tri-snRNP complex
U5 snRNP
androgen receptor binding
poly(A) RNA binding
ribonucleoprotein complex binding
RNA binding
transcription coactivator activity
gene expression
mRNA splicing, via spliceosome
positive regulation of transcription from RNA polymerase II promoter
RNA localization
RNA splicing
RNA splicing, via transesterification reactions
spliceosomal complex assembly
spliceosomal tri-snRNP complex assembly
Gene Ontology Biological Process:
gene expression
mRNA splicing, via spliceosome
positive regulation of transcription from RNA polymerase II promoter
RNA localization
RNA splicing
RNA splicing, via transesterification reactions
spliceosomal complex assembly
spliceosomal tri-snRNP complex assembly
Gene Ontology Molecular Function:
androgen receptor binding
poly(A) RNA binding
ribonucleoprotein complex binding
RNA binding
transcription coactivator activity
Gene Ontology Cellular Component:
catalytic step 2 spliceosome
membrane
nuclear speck
nucleoplasm
nucleus
spliceosomal complex
U4/U6 x U5 tri-snRNP complex
U5 snRNP
Keywords:
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Retinitis pigmentosa
Spliceosome
mRNA processing
mRNA splicing
Interacts With:
P10398; O95400; Q13123; Q8WWY3

Publication

PubMed ID:
10561546 10788320 10848612 14702039 11780052 15489334 17974005 12039962 11991638 16723661 18669648 19690332 20068231 21269460 24275569 21549338 22235333