Names & Taxonomy

Uniprot ID:
O94813
Entry Name:
SLIT2_HUMAN
Status:
reviewed
Protein Names:
Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product]
Gene Names:
SLIT2 SLIL3
Gene Names Primary:
SLIT2
Organism:
Homo sapiens (Human)

Structure

Length:
1529
Sequence:
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
Gene Ontology Go:
cell surface
cytoplasm
extracellular exosome
extracellular region
extracellular space
membrane
plasma membrane
proteinaceous extracellular matrix
calcium ion binding
GTPase inhibitor activity
heparin binding
identical protein binding
laminin-1 binding
protein homodimerization activity
proteoglycan binding
Roundabout binding
apoptotic process involved in luteolysis
axon extension involved in axon guidance
axon guidance
branching morphogenesis of an epithelial tube
cell migration involved in sprouting angiogenesis
cellular response to heparin
cellular response to hormone stimulus
chemorepulsion involved in postnatal olfactory bulb interneuron migration
corticospinal neuron axon guidance through spinal cord
induction of negative chemotaxis
motor neuron axon guidance
negative chemotaxis
negative regulation of actin filament polymerization
negative regulation of cell growth
negative regulation of cell migration
negative regulation of cellular response to growth factor stimulus
negative regulation of chemokine-mediated signaling pathway
negative regulation of endothelial cell migration
negative regulation of GTPase activity
negative regulation of inflammatory response
negative regulation of lamellipodium assembly
negative regulation of leukocyte chemotaxis
negative regulation of monocyte chemotaxis
negative regulation of mononuclear cell migration
negative regulation of neutrophil chemotaxis
negative regulation of protein phosphorylation
negative regulation of retinal ganglion cell axon guidance
negative regulation of small GTPase mediated signal transduction
negative regulation of smooth muscle cell chemotaxis
negative regulation of smooth muscle cell migration
negative regulation of vascular permeability
positive regulation of apoptotic process
positive regulation of axonogenesis
response to cortisol
response to nutrient levels
retinal ganglion cell axon guidance
Roundabout signaling pathway
spinal cord development
ureteric bud development
Gene Ontology Biological Process:
apoptotic process involved in luteolysis
axon extension involved in axon guidance
axon guidance
branching morphogenesis of an epithelial tube
cell migration involved in sprouting angiogenesis
cellular response to heparin
cellular response to hormone stimulus
chemorepulsion involved in postnatal olfactory bulb interneuron migration
corticospinal neuron axon guidance through spinal cord
induction of negative chemotaxis
motor neuron axon guidance
negative chemotaxis
negative regulation of actin filament polymerization
negative regulation of cell growth
negative regulation of cell migration
negative regulation of cellular response to growth factor stimulus
negative regulation of chemokine-mediated signaling pathway
negative regulation of endothelial cell migration
negative regulation of GTPase activity
negative regulation of inflammatory response
negative regulation of lamellipodium assembly
negative regulation of leukocyte chemotaxis
negative regulation of monocyte chemotaxis
negative regulation of mononuclear cell migration
negative regulation of neutrophil chemotaxis
negative regulation of protein phosphorylation
negative regulation of retinal ganglion cell axon guidance
negative regulation of small GTPase mediated signal transduction
negative regulation of smooth muscle cell chemotaxis
negative regulation of smooth muscle cell migration
negative regulation of vascular permeability
positive regulation of apoptotic process
positive regulation of axonogenesis
response to cortisol
response to nutrient levels
retinal ganglion cell axon guidance
Roundabout signaling pathway
spinal cord development
ureteric bud development
Gene Ontology Molecular Function:
calcium ion binding
GTPase inhibitor activity
heparin binding
identical protein binding
laminin-1 binding
protein homodimerization activity
proteoglycan binding
Roundabout binding
Gene Ontology Cellular Component:
cell surface
cytoplasm
extracellular exosome
extracellular region
extracellular space
membrane
plasma membrane
proteinaceous extracellular matrix
Keywords:
3D-structure
Alternative splicing
Chemotaxis
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Heparin-binding
Leucine-rich repeat
Neurogenesis
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Interacts With:
Itself

Publication

PubMed ID:
9813312 10349621 10102268 15489334 10975526 10864954 11309622 11222645 11404413 11239147 12200164 17704564 17848514 19498462