Names & Taxonomy

Uniprot ID:
O94808
Entry Name:
GFPT2_HUMAN
Status:
reviewed
Protein Names:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2)
Gene Names:
GFPT2
Gene Names Primary:
GFPT2
Organism:
Homo sapiens (Human)

Structure

Length:
682
Sequence:
MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKRGKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHNGIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEGAFALVFKSVHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMKRLDSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSASDDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDHLKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYCKDRGALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLEEKIHDLALELYTQRSLLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALIDKQMPVIMVIMKDPCFAKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFHLAVLRGYDVDFPRNLAKSVTVE
Proteomes:
UP000005640

Function

Function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Pathway:
Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.
Catalytic Activity:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
Active Site:
ACT_SITE 2 2 For GATase activity.
Cross Reference Drug Bank:
DB00130
Gene Ontology Go:
cytosol
carbohydrate binding
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
energy reserve metabolic process
fructose 6-phosphate metabolic process
glutamine metabolic process
post-translational protein modification
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
UDP-N-acetylglucosamine biosynthetic process
UDP-N-acetylglucosamine metabolic process
Gene Ontology Biological Process:
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
energy reserve metabolic process
fructose 6-phosphate metabolic process
glutamine metabolic process
post-translational protein modification
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
UDP-N-acetylglucosamine biosynthetic process
UDP-N-acetylglucosamine metabolic process
Gene Ontology Molecular Function:
carbohydrate binding
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Gene Ontology Cellular Component:
cytosol
Keywords:
Aminotransferase
Complete proteome
Glutamine amidotransferase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transferase
Interacts With:
Q9NUX5

Publication

PubMed ID:
10198162 15489334 18669648 21406692