Names & Taxonomy
- Uniprot ID:
- O94808
- Entry Name:
- GFPT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2)
- Gene Names:
- GFPT2
- Gene Names Primary:
- GFPT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 682
- Sequence:
- MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKRGKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHNGIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEGAFALVFKSVHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMKRLDSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSASDDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDHLKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYCKDRGALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLEEKIHDLALELYTQRSLLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALIDKQMPVIMVIMKDPCFAKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFHLAVLRGYDVDFPRNLAKSVTVE
- Proteomes:
- UP000005640
Function
- Function:
- Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
- Pathway:
- Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.
- Catalytic Activity:
- L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
- Active Site:
- ACT_SITE 2 2 For GATase activity.
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytosol
carbohydrate binding
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
energy reserve metabolic process
fructose 6-phosphate metabolic process
glutamine metabolic process
post-translational protein modification
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
UDP-N-acetylglucosamine biosynthetic process
UDP-N-acetylglucosamine metabolic process - Gene Ontology Biological Process:
- cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
energy reserve metabolic process
fructose 6-phosphate metabolic process
glutamine metabolic process
post-translational protein modification
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
UDP-N-acetylglucosamine biosynthetic process
UDP-N-acetylglucosamine metabolic process - Gene Ontology Molecular Function:
- carbohydrate binding
glutamine-fructose-6-phosphate transaminase (isomerizing) activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- Aminotransferase
Complete proteome
Glutamine amidotransferase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transferase - Interacts With:
- Q9NUX5