Names & Taxonomy
- Uniprot ID:
- O94768
- Entry Name:
- ST17B_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2)
- Gene Names:
- STK17B DRAK2
- Gene Names Primary:
- STK17B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 372
- Sequence:
- MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSLPNPHELVSDLLC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Active Site:
- ACT_SITE 158 158 Proton acceptor.
- Gene Ontology Go:
- actin cytoskeleton
endoplasmic reticulum-Golgi intermediate compartment
nucleus
plasma membrane
ATP binding
protein kinase activity
protein serine/threonine kinase activity
apoptotic process
intracellular signal transduction
positive regulation of fibroblast apoptotic process
protein autophosphorylation
protein phosphorylation - Gene Ontology Biological Process:
- apoptotic process
intracellular signal transduction
positive regulation of fibroblast apoptotic process
protein autophosphorylation
protein phosphorylation - Gene Ontology Molecular Function:
- ATP binding
protein kinase activity
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- actin cytoskeleton
endoplasmic reticulum-Golgi intermediate compartment
nucleus
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Apoptosis
Cell membrane
Complete proteome
Kinase
Membrane
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase