Names & Taxonomy
- Uniprot ID:
- O76074
- Entry Name:
- PDE5A_HUMAN
- Status:
- reviewed
- Protein Names:
- cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)
- Gene Names:
- PDE5A PDE5
- Gene Names Primary:
- PDE5A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 875
- Sequence:
- MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
- Proteomes:
- UP000005640
Function
- Function:
- Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).
- Pathway:
- Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
- Catalytic Activity:
- Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A and is effective in the treatment of penile erectile dysfunction. Also inhibited by zaprinast.
- Active Site:
- ACT_SITE 613 613 Proton donor.
- Cross Reference Drug Bank:
- DB06237 DB00201 DB00975 DB00806 DB00203 DB00820 DB00277 DB06267 DB00862
- Gene Ontology Go:
- cytosol
3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cGMP binding
metal ion binding
blood coagulation
cGMP catabolic process
negative regulation of cardiac muscle contraction
negative regulation of T cell proliferation
positive regulation of cardiac muscle hypertrophy
positive regulation of MAP kinase activity
positive regulation of oocyte development
regulation of cGMP metabolic process
relaxation of cardiac muscle
signal transduction - Gene Ontology Biological Process:
- blood coagulation
cGMP catabolic process
negative regulation of cardiac muscle contraction
negative regulation of T cell proliferation
positive regulation of cardiac muscle hypertrophy
positive regulation of MAP kinase activity
positive regulation of oocyte development
regulation of cGMP metabolic process
relaxation of cardiac muscle
signal transduction - Gene Ontology Molecular Function:
- 3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cGMP binding
metal ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Allosteric enzyme
Alternative splicing
Complete proteome
Hydrolase
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
cGMP
cGMP-binding