Names & Taxonomy
- Uniprot ID:
- O76054
- Entry Name:
- S14L2_HUMAN
- Status:
- reviewed
- Protein Names:
- SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (hTAP) (Squalene transfer protein) (Supernatant protein factor) (SPF)
- Gene Names:
- SEC14L2 C22orf6 KIAA1186 KIAA1658
- Gene Names Primary:
- SEC14L2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 403
- Sequence:
- MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSDPGIYVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.
Function
- Function:
- Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
- Cross Reference Drug Bank:
- DB00163
- Gene Ontology Go:
- cytoplasm
extracellular exosome
integral component of membrane
nucleus
phospholipid binding
transporter activity
vitamin E binding
positive regulation of transcription, DNA-templated
regulation of cholesterol biosynthetic process
transcription, DNA-templated - Gene Ontology Biological Process:
- positive regulation of transcription, DNA-templated
regulation of cholesterol biosynthetic process
transcription, DNA-templated - Gene Ontology Molecular Function:
- phospholipid binding
transporter activity
vitamin E binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
integral component of membrane
nucleus - Keywords:
- 3D-structure
Activator
Alternative splicing
Complete proteome
Cytoplasm
Lipid-binding
Nucleus
Polymorphism
Reference proteome
Transcription
Transcription regulation
Transport