Names & Taxonomy
- Uniprot ID:
- O75911
- Entry Name:
- DHRS3_HUMAN
- Status:
- reviewed
- Protein Names:
- Short-chain dehydrogenase/reductase 3 (EC 1.1.1.300) (DD83.1) (Retinal short-chain dehydrogenase/reductase 1) (retSDR1) (Retinol dehydrogenase 17) (Short chain dehydrogenase/reductase family 16C member 1)
- Gene Names:
- DHRS3 RDH17 SDR16C1 UNQ2424/PRO4983
- Gene Names Orf:
- UNQ2424/PRO4983
- Gene Names Primary:
- DHRS3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 302
- Sequence:
- MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
- Catalytic Activity:
- All-trans-retinol + NADP(+) = all-trans-retinal + NADPH.
- Active Site:
- ACT_SITE 188 188 Proton acceptor.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
photoreceptor outer segment membrane
electron carrier activity
NADP-retinol dehydrogenase activity
nucleotide binding
retinol dehydrogenase activity
bone morphogenesis
cardiac septum morphogenesis
negative regulation of retinoic acid receptor signaling pathway
outflow tract morphogenesis
palate development
phototransduction, visible light
regulation of ossification
retinoid metabolic process
retinol metabolic process
visual perception - Gene Ontology Biological Process:
- bone morphogenesis
cardiac septum morphogenesis
negative regulation of retinoic acid receptor signaling pathway
outflow tract morphogenesis
palate development
phototransduction, visible light
regulation of ossification
retinoid metabolic process
retinol metabolic process
visual perception - Gene Ontology Molecular Function:
- electron carrier activity
NADP-retinol dehydrogenase activity
nucleotide binding
retinol dehydrogenase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
photoreceptor outer segment membrane - Keywords:
- Alternative splicing
Complete proteome
Membrane
NADP
Oxidoreductase
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix