Names & Taxonomy
- Uniprot ID:
- A0A024QZA8
- Entry Name:
- A0A024QZA8_HUMAN
- Status:
- unreviewed
- Protein Names:
- EPH receptor A2, isoform CRA_a
- Gene Names:
- EPHA2 hCG_24712
- Gene Names Orf:
- hCG_24712
- Gene Names Primary:
- EPHA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 976
- Sequence:
- MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 739 739 Proton acceptor.
- Gene Ontology Go:
- integral component of plasma membrane
ATP binding
ephrin receptor activity
axial mesoderm formation
bone remodeling
branching involved in mammary gland duct morphogenesis
lens fiber cell morphogenesis
mammary gland epithelial cell proliferation
neural tube development
neuron differentiation
notochord cell development
notochord formation
osteoblast differentiation
osteoclast differentiation
post-anal tail morphogenesis
regulation of angiogenesis
regulation of blood vessel endothelial cell migration
skeletal system development
vasculogenesis - Gene Ontology Biological Process:
- axial mesoderm formation
bone remodeling
branching involved in mammary gland duct morphogenesis
lens fiber cell morphogenesis
mammary gland epithelial cell proliferation
neural tube development
neuron differentiation
notochord cell development
notochord formation
osteoblast differentiation
osteoclast differentiation
post-anal tail morphogenesis
regulation of angiogenesis
regulation of blood vessel endothelial cell migration
skeletal system development
vasculogenesis - Gene Ontology Molecular Function:
- ATP binding
ephrin receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
- Keywords:
- ATP-binding
Kinase
Membrane
Nucleotide-binding
Receptor
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Publication
- PubMed ID:
- 11181995