Names & Taxonomy
- Uniprot ID:
- O75900
- Entry Name:
- MMP23_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-23 (MMP-23) (EC 3.4.24.-) (Femalysin) (MIFR-1) (Matrix metalloproteinase-21) (MMP-21) (Matrix metalloproteinase-22) (MMP-22) [Cleaved into: Matrix metalloproteinase-23, soluble form]
- Gene Names:
- MMP23A MMP21; MMP23B MMP21 MMP22
- Gene Names Orf:
- ;
- Gene Names Primary:
- MMP23A; MMP23B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 390
- Sequence:
- MGRGARVPSEAPGAGVERRWLGAALVALCLLPALVLLARLGAPAVPAWSAAQGDVAALGLSAVPPTRVPGPLAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGCLDRLFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFRCGQKILHKKGKVYWYKDQEPLEFSYPGYLALGEAHLSIIANAVNEGTYTCVVRRQQRVLTTYSWRVRVRG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by TIMP2.
- Active Site:
- ACT_SITE 212 212
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
intracellular
proteinaceous extracellular matrix
metalloendopeptidase activity
metallopeptidase activity
zinc ion binding
proteolysis
reproduction - Gene Ontology Biological Process:
- proteolysis
reproduction - Gene Ontology Molecular Function:
- metalloendopeptidase activity
metallopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
intracellular
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Immunoglobulin domain
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Zinc
Zymogen