Names & Taxonomy
- Uniprot ID:
- O75762
- Entry Name:
- TRPA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120)
- Gene Names:
- TRPA1 ANKTM1
- Gene Names Primary:
- TRPA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1119
- Sequence:
- MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 902 922 Pore-forming.
Function
- Function:
- Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by ruthenium red, a potent blocker of TRPV channels.
- Cross Reference Drug Bank:
- DB00825
- Gene Ontology Go:
- integral component of plasma membrane
intracellular
plasma membrane
stereocilium bundle
calcium-release channel activity
channel activity
temperature-gated cation channel activity
calcium ion transmembrane transport
cell surface receptor signaling pathway
detection of chemical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
ion transmembrane transport
ion transport
protein homotetramerization
release of sequestered calcium ion into cytosol
response to cold
response to drug
response to hydrogen peroxide
response to organic cyclic compound
response to organic substance
response to pain
sensory perception of pain
thermoception
transmembrane transport - Gene Ontology Biological Process:
- calcium ion transmembrane transport
cell surface receptor signaling pathway
detection of chemical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
ion transmembrane transport
ion transport
protein homotetramerization
release of sequestered calcium ion into cytosol
response to cold
response to drug
response to hydrogen peroxide
response to organic cyclic compound
response to organic substance
response to pain
sensory perception of pain
thermoception
transmembrane transport - Gene Ontology Molecular Function:
- calcium-release channel activity
channel activity
temperature-gated cation channel activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
intracellular
plasma membrane
stereocilium bundle - Keywords:
- 3D-structure
ANK repeat
Cell membrane
Coiled coil
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Reference proteome
Repeat
Sensory transduction
Transmembrane
Transmembrane helix
Transport