Names & Taxonomy
- Uniprot ID:
- O75533
- Entry Name:
- SF3B1_HUMAN
- Status:
- reviewed
- Protein Names:
- Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)
- Gene Names:
- SF3B1 SAP155
- Gene Names Primary:
- SF3B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1304
- Sequence:
- MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKGSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.
Function
- Function:
- Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
- Gene Ontology Go:
- catalytic step 2 spliceosome
nuclear speck
nucleoplasm
nucleus
spliceosomal complex
U11/U12 snRNP
U12-type spliceosomal complex
U2 snRNP
U2-type prespliceosome
mRNA binding
poly(A) RNA binding
gene expression
mRNA splicing, via spliceosome
positive regulation of gene expression, epigenetic
regulation of gene expression, epigenetic
RNA splicing
RNA splicing, via transesterification reactions
spliceosomal complex assembly - Gene Ontology Biological Process:
- gene expression
mRNA splicing, via spliceosome
positive regulation of gene expression, epigenetic
regulation of gene expression, epigenetic
RNA splicing
RNA splicing, via transesterification reactions
spliceosomal complex assembly - Gene Ontology Molecular Function:
- mRNA binding
poly(A) RNA binding - Gene Ontology Cellular Component:
- catalytic step 2 spliceosome
nuclear speck
nucleoplasm
nucleus
spliceosomal complex
U11/U12 snRNP
U12-type spliceosomal complex
U2 snRNP
U2-type prespliceosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Citrullination
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
Spliceosome
Ubl conjugation
mRNA processing
mRNA splicing - Interacts With:
- Q96I25