Names & Taxonomy
- Uniprot ID:
- O75521
- Entry Name:
- ECI2_HUMAN
- Status:
- reviewed
- Protein Names:
- Enoyl-CoA delta isomerase 2, mitochondrial (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)
- Gene Names:
- ECI2 DRS1 HCA88 PECI
- Gene Names Primary:
- ECI2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 394
- Sequence:
- MAMAYLAWRLARRSCPSSLQVTSFPVVQLHMNRTAMRASQKDFENSMNQVKLLKKDPGNEVKLKLYALYKQATEGPCNMPKPGVFDLINKAKWDAWNALGSLPKEAARQNYVDLVSSLSPSLESSSQVEPGTDRKSTGFETLVVTSEDGITKIMFNRPKKKNAINTEMYHEIMRALKAASKDDSIITVLTGNGDYYSSGNDLTNFTDIPPGGVEEKAKNNAVLLREFVGCFIDFPKPLIAVVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEGCSSYTFPKIMSPAKATEMLIFGKKLTAGEACAQGLVTEVFPDSTFQKEVWTRLKAFAKLPPNALRISKEVIRKREREKLHAVNAEECNVLQGRWLSDECTNAVVNFLSRKSKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Mitochondrion
Function
- Function:
- Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).
- Catalytic Activity:
- (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.
- Gene Ontology Go:
- intracellular membrane-bounded organelle
membrane
mitochondrion
nucleoplasm
peroxisomal matrix
dodecenoyl-CoA delta-isomerase activity
fatty-acyl-CoA binding
receptor binding
fatty acid beta-oxidation
fatty acid catabolic process - Gene Ontology Biological Process:
- fatty acid beta-oxidation
fatty acid catabolic process - Gene Ontology Molecular Function:
- dodecenoyl-CoA delta-isomerase activity
fatty-acyl-CoA binding
receptor binding - Gene Ontology Cellular Component:
- intracellular membrane-bounded organelle
membrane
mitochondrion
nucleoplasm
peroxisomal matrix - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Isomerase
Mitochondrion
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide