Names & Taxonomy
- Uniprot ID:
- O75489
- Entry Name:
- NDUS3_HUMAN
- Status:
- reviewed
- Protein Names:
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)
- Gene Names:
- NDUFS3
- Gene Names Primary:
- NDUFS3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 264
- Sequence:
- MAAAAVARLWWRGILGASALTRGTGRPSVLLLPVRRESAGADTRPTVRPRNDVAHKQLSAFGEYVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPVYRQPPESLKLEAGDKKPDAK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane.
Function
- Function:
- Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
- Catalytic Activity:
- NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).; NADH + acceptor = NAD(+) + reduced acceptor.
- Cross Reference Drug Bank:
- DB00997
- Gene Ontology Go:
- mitochondrial matrix
mitochondrial membrane
mitochondrial respiratory chain complex I
mitochondrion
myelin sheath
nucleus
electron carrier activity
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase activity
cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
negative regulation of cell growth
negative regulation of intrinsic apoptotic signaling pathway
reactive oxygen species metabolic process
respiratory electron transport chain
small molecule metabolic process
substantia nigra development - Gene Ontology Biological Process:
- cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
negative regulation of cell growth
negative regulation of intrinsic apoptotic signaling pathway
reactive oxygen species metabolic process
respiratory electron transport chain
small molecule metabolic process
substantia nigra development - Gene Ontology Molecular Function:
- electron carrier activity
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrial membrane
mitochondrial respiratory chain complex I
mitochondrion
myelin sheath
nucleus - Keywords:
- Alternative splicing
Complete proteome
Direct protein sequencing
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
NAD
Oxidoreductase
Polymorphism
Reference proteome
Respiratory chain
Transit peptide
Transport
Ubiquinone - Interacts With:
- O75306