Names & Taxonomy
- Uniprot ID:
- O75330
- Entry Name:
- HMMR_HUMAN
- Status:
- reviewed
- Protein Names:
- Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)
- Gene Names:
- HMMR IHABP RHAMM
- Gene Names Primary:
- HMMR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 724
- Sequence:
- MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell surface. Cytoplasm
Function
- Function:
- Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.
- Cross Reference Drug Bank:
- DB08818
- Gene Ontology Go:
- cell surface
cytoplasm
membrane
plasma membrane
hyaluronic acid binding
carbohydrate metabolic process
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- hyaluronic acid binding
- Gene Ontology Cellular Component:
- cell surface
cytoplasm
membrane
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
Glycoprotein
Hyaluronic acid
Phosphoprotein
Polymorphism
Reference proteome
Repeat - Interacts With:
- Q8NDC4