Names & Taxonomy

Uniprot ID:
O75330
Entry Name:
HMMR_HUMAN
Status:
reviewed
Protein Names:
Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)
Gene Names:
HMMR IHABP RHAMM
Gene Names Primary:
HMMR
Organism:
Homo sapiens (Human)

Structure

Length:
724
Sequence:
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell surface. Cytoplasm

Function

Function:
Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.
Cross Reference Drug Bank:
DB08818
Gene Ontology Go:
cell surface
cytoplasm
membrane
plasma membrane
hyaluronic acid binding
carbohydrate metabolic process
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
glycosaminoglycan metabolic process
hyaluronan catabolic process
hyaluronan metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
hyaluronic acid binding
Gene Ontology Cellular Component:
cell surface
cytoplasm
membrane
plasma membrane
Keywords:
Alternative splicing
Complete proteome
Cytoplasm
Glycoprotein
Hyaluronic acid
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Interacts With:
Q8NDC4

Publication

PubMed ID:
8890751 9601098 14702039 15372022 15489334 18669648 21269460