Names & Taxonomy
- Uniprot ID:
- O75015
- Entry Name:
- FCG3B_HUMAN
- Status:
- reviewed
- Protein Names:
- Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)
- Gene Names:
- FCGR3B CD16B FCG3 FCGR3 IGFR3
- Gene Names Primary:
- FCGR3B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 233
- Sequence:
- MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFSPPGYQVSFCLVMVLLFAVDTGLYFSVKTNI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.
Function
- Function:
- Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
- Cross Reference Drug Bank:
- DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072
- Gene Ontology Go:
- anchored component of membrane
extracellular exosome
plasma membrane
immune response
mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
xenophagy - Gene Ontology Biological Process:
- immune response
mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
xenophagy - Gene Ontology Cellular Component:
- anchored component of membrane
extracellular exosome
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
GPI-anchor
Glycoprotein
IgG-binding protein
Immunoglobulin domain
Lipoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal