Names & Taxonomy

Uniprot ID:
O75015
Entry Name:
FCG3B_HUMAN
Status:
reviewed
Protein Names:
Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)
Gene Names:
FCGR3B CD16B FCG3 FCGR3 IGFR3
Gene Names Primary:
FCGR3B
Organism:
Homo sapiens (Human)

Structure

Length:
233
Sequence:
MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFSPPGYQVSFCLVMVLLFAVDTGLYFSVKTNI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.

Function

Function:
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Cross Reference Drug Bank:
DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072
Gene Ontology Go:
anchored component of membrane
extracellular exosome
plasma membrane
immune response
mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
xenophagy
Gene Ontology Biological Process:
immune response
mitophagy in response to mitochondrial depolarization
positive regulation of defense response to virus by host
xenophagy
Gene Ontology Cellular Component:
anchored component of membrane
extracellular exosome
plasma membrane
Keywords:
3D-structure
Cell membrane
Complete proteome
Disulfide bond
GPI-anchor
Glycoprotein
IgG-binding protein
Immunoglobulin domain
Lipoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal

Publication

PubMed ID:
2526846 2967436 2521732 2525780 15245367 16710414 7836402 10917521 11021536 9028335