Names & Taxonomy

Uniprot ID:
O60894
Entry Name:
RAMP1_HUMAN
Status:
reviewed
Protein Names:
Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)
Gene Names:
RAMP1
Gene Names Primary:
RAMP1
Organism:
Homo sapiens (Human)

Structure

Length:
148
Sequence:
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
Cross Reference Drug Bank:
DB01278
Gene Ontology Go:
cell surface
extracellular space
integral component of plasma membrane
intracellular
plasma membrane
receptor complex
calcitonin receptor activity
calcitonin receptor binding
coreceptor activity
protein transporter activity
receptor activity
angiogenesis
calcium ion transport
intracellular protein transport
positive regulation of cAMP biosynthetic process
positive regulation of protein glycosylation
protein localization to plasma membrane
protein transport
receptor internalization
regulation of G-protein coupled receptor protein signaling pathway
Gene Ontology Biological Process:
angiogenesis
calcium ion transport
intracellular protein transport
positive regulation of cAMP biosynthetic process
positive regulation of protein glycosylation
protein localization to plasma membrane
protein transport
receptor internalization
regulation of G-protein coupled receptor protein signaling pathway
Gene Ontology Molecular Function:
calcitonin receptor activity
calcitonin receptor binding
coreceptor activity
protein transporter activity
receptor activity
Gene Ontology Cellular Component:
cell surface
extracellular space
integral component of plasma membrane
intracellular
plasma membrane
receptor complex
Keywords:
3D-structure
Complete proteome
Disulfide bond
Membrane
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9620797 15489334 18725456 20826335