Names & Taxonomy
- Uniprot ID:
- O60882
- Entry Name:
- MMP20_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-20 (MMP-20) (EC 3.4.24.-) (Enamel metalloproteinase) (Enamelysin)
- Gene Names:
- MMP20
- Gene Names Primary:
- MMP20
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 483
- Sequence:
- MKVLPASGLAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQGPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.
- Catalytic Activity:
- Cleaves aggrecan at the 360-Asn-|-Phe-361 site.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 227 227
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular region
extracellular space
proteinaceous extracellular matrix
calcium ion binding
metalloendopeptidase activity
zinc ion binding
amelogenesis
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
protein catabolic process
proteolysis
regulation of enamel mineralization - Gene Ontology Biological Process:
- amelogenesis
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
protein catabolic process
proteolysis
regulation of enamel mineralization - Gene Ontology Molecular Function:
- calcium ion binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Amelogenesis imperfecta
Autocatalytic cleavage
Calcium
Complete proteome
Disulfide bond
Extracellular matrix
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen