Names & Taxonomy
- Uniprot ID:
- O60721
- Entry Name:
- NCKX1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger) (Solute carrier family 24 member 1)
- Gene Names:
- SLC24A1 KIAA0702 NCKX1
- Gene Names Primary:
- SLC24A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1099
- Sequence:
- MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPSKPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTSSRTLTYYTSTSSRQIVKKYTPTPRGEMKSYSPTQVREKVKYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLKRIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPATSEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVKPTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
- Gene Ontology Go:
- integral component of plasma membrane
membrane
outer membrane
plasma membrane
calcium channel activity
calcium ion binding
calcium, potassium:sodium antiporter activity
potassium ion binding
sodium ion binding
symporter activity
calcium ion transmembrane transport
calcium ion transport
cellular calcium ion homeostasis
ion transport
phototransduction, visible light
response to light intensity
rhodopsin mediated signaling pathway
sodium ion transmembrane transport
transmembrane transport
transport
visual perception - Gene Ontology Biological Process:
- calcium ion transmembrane transport
calcium ion transport
cellular calcium ion homeostasis
ion transport
phototransduction, visible light
response to light intensity
rhodopsin mediated signaling pathway
sodium ion transmembrane transport
transmembrane transport
transport
visual perception - Gene Ontology Molecular Function:
- calcium, potassium:sodium antiporter activity
calcium channel activity
calcium ion binding
potassium ion binding
sodium ion binding
symporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
outer membrane
plasma membrane - Keywords:
- Alternative splicing
Antiport
Calcium
Calcium transport
Complete proteome
Congenital stationary night blindness
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Sensory transduction
Signal
Symport
Transmembrane
Transmembrane helix
Transport
Vision - Interacts With:
- P16333