Names & Taxonomy

Uniprot ID:
O60721
Entry Name:
NCKX1_HUMAN
Status:
reviewed
Protein Names:
Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger) (Solute carrier family 24 member 1)
Gene Names:
SLC24A1 KIAA0702 NCKX1
Gene Names Primary:
SLC24A1
Organism:
Homo sapiens (Human)

Structure

Length:
1099
Sequence:
MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPSKPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTSSRTLTYYTSTSSRQIVKKYTPTPRGEMKSYSPTQVREKVKYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLKRIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPATSEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVKPTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
Gene Ontology Go:
integral component of plasma membrane
membrane
outer membrane
plasma membrane
calcium channel activity
calcium ion binding
calcium, potassium:sodium antiporter activity
potassium ion binding
sodium ion binding
symporter activity
calcium ion transmembrane transport
calcium ion transport
cellular calcium ion homeostasis
ion transport
phototransduction, visible light
response to light intensity
rhodopsin mediated signaling pathway
sodium ion transmembrane transport
transmembrane transport
transport
visual perception
Gene Ontology Biological Process:
calcium ion transmembrane transport
calcium ion transport
cellular calcium ion homeostasis
ion transport
phototransduction, visible light
response to light intensity
rhodopsin mediated signaling pathway
sodium ion transmembrane transport
transmembrane transport
transport
visual perception
Gene Ontology Molecular Function:
calcium, potassium:sodium antiporter activity
calcium channel activity
calcium ion binding
potassium ion binding
sodium ion binding
symporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
membrane
outer membrane
plasma membrane
Keywords:
Alternative splicing
Antiport
Calcium
Calcium transport
Complete proteome
Congenital stationary night blindness
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Sensory transduction
Signal
Symport
Transmembrane
Transmembrane helix
Transport
Vision
Interacts With:
P16333

Publication

PubMed ID:
9856482 9478004 16572171 15489334 9734811 10608890 19690332 20850105