Names & Taxonomy
- Uniprot ID:
- O60669
- Entry Name:
- MOT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)
- Gene Names:
- SLC16A7 MCT2
- Gene Names Primary:
- SLC16A7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 478
- Sequence:
- MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
- Cross Reference Drug Bank:
- DB01440 DB04398 DB04552 DB01032 DB00119
- Gene Ontology Go:
- cytoplasm
integral component of plasma membrane
plasma membrane
lactate transmembrane transporter activity
pyruvate secondary active transmembrane transporter activity
pyruvate transmembrane transporter activity
symporter activity
lactate transmembrane transport
plasma membrane lactate transport
pyruvate transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- lactate transmembrane transport
plasma membrane lactate transport
pyruvate transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- lactate transmembrane transporter activity
pyruvate secondary active transmembrane transporter activity
pyruvate transmembrane transporter activity
symporter activity - Gene Ontology Cellular Component:
- cytoplasm
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport