Names & Taxonomy

Uniprot ID:
O60669
Entry Name:
MOT2_HUMAN
Status:
reviewed
Protein Names:
Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)
Gene Names:
SLC16A7 MCT2
Gene Names Primary:
SLC16A7
Organism:
Homo sapiens (Human)

Structure

Length:
478
Sequence:
MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
Cross Reference Drug Bank:
DB01440 DB04398 DB04552 DB01032 DB00119
Gene Ontology Go:
cytoplasm
integral component of plasma membrane
plasma membrane
lactate transmembrane transporter activity
pyruvate secondary active transmembrane transporter activity
pyruvate transmembrane transporter activity
symporter activity
lactate transmembrane transport
plasma membrane lactate transport
pyruvate transmembrane transport
transmembrane transport
Gene Ontology Biological Process:
lactate transmembrane transport
plasma membrane lactate transport
pyruvate transmembrane transport
transmembrane transport
Gene Ontology Molecular Function:
lactate transmembrane transporter activity
pyruvate secondary active transmembrane transporter activity
pyruvate transmembrane transporter activity
symporter activity
Gene Ontology Cellular Component:
cytoplasm
integral component of plasma membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9786900 14702039 16541075 15489334 15505343