Names & Taxonomy

Uniprot ID:
O60662
Entry Name:
KLH41_HUMAN
Status:
reviewed
Protein Names:
Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin)
Gene Names:
KLHL41 KBTBD10 KRP1
Gene Names Primary:
KLHL41
Organism:
Homo sapiens (Human)

Structure

Length:
606
Sequence:
MDSQRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.
Gene Ontology Go:
Cul3-RING ubiquitin ligase complex
cytoplasm
cytoskeleton
endoplasmic reticulum membrane
M band
nucleus
plasma membrane
pseudopodium
ruffle
sarcoplasmic reticulum membrane
myofibril assembly
protein ubiquitination
regulation of lateral pseudopodium assembly
regulation of myoblast differentiation
regulation of myoblast proliferation
regulation of skeletal muscle cell differentiation
sarcomere organization
skeletal muscle cell differentiation
skeletal muscle fiber development
striated muscle contraction
Gene Ontology Biological Process:
myofibril assembly
protein ubiquitination
regulation of lateral pseudopodium assembly
regulation of myoblast differentiation
regulation of myoblast proliferation
regulation of skeletal muscle cell differentiation
sarcomere organization
skeletal muscle cell differentiation
skeletal muscle fiber development
striated muscle contraction
Gene Ontology Cellular Component:
Cul3-RING ubiquitin ligase complex
cytoplasm
cytoskeleton
endoplasmic reticulum membrane
M band
nucleus
plasma membrane
pseudopodium
ruffle
sarcoplasmic reticulum membrane
Keywords:
Alternative splicing
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Endoplasmic reticulum
Kelch repeat
Membrane
Nemaline myopathy
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Sarcoplasmic reticulum
Ubl conjugation
Interacts With:
P20929; P20929-4; Q96PM5

Publication

PubMed ID:
9655184 10713668 15815621 15489334 15983046 19424503 24268659