Names & Taxonomy

Uniprot ID:
O60488
Entry Name:
ACSL4_HUMAN
Status:
reviewed
Protein Names:
Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4)
Gene Names:
ACSL4 ACS4 FACL4 LACS4
Gene Names Primary:
ACSL4
Organism:
Homo sapiens (Human)

Structure

Length:
711
Sequence:
MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion outer membrane

Function

Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
Catalytic Activity:
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Cross Reference Drug Bank:
DB00159 DB00412
Gene Ontology Go:
cytoplasm
endoplasmic reticulum membrane
ER-mitochondrion membrane contact site
extracellular exosome
integral component of membrane
lipid particle
membrane
mitochondrial outer membrane
neuronal cell body
peroxisomal membrane
arachidonate-CoA ligase activity
ATP binding
long-chain fatty acid-CoA ligase activity
very long-chain fatty acid-CoA ligase activity
cellular lipid metabolic process
dendritic spine development
embryonic process involved in female pregnancy
fatty acid transport
lipid biosynthetic process
lipid metabolic process
long-chain fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
negative regulation of prostaglandin secretion
positive regulation of cell growth
response to interleukin-15
response to nutrient
small molecule metabolic process
triglyceride biosynthetic process
Gene Ontology Biological Process:
cellular lipid metabolic process
dendritic spine development
embryonic process involved in female pregnancy
fatty acid transport
lipid biosynthetic process
lipid metabolic process
long-chain fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
negative regulation of prostaglandin secretion
positive regulation of cell growth
response to interleukin-15
response to nutrient
small molecule metabolic process
triglyceride biosynthetic process
Gene Ontology Molecular Function:
arachidonate-CoA ligase activity
ATP binding
long-chain fatty acid-CoA ligase activity
very long-chain fatty acid-CoA ligase activity
Gene Ontology Cellular Component:
cytoplasm
endoplasmic reticulum membrane
ER-mitochondrion membrane contact site
extracellular exosome
integral component of membrane
lipid particle
membrane
mitochondrial outer membrane
neuronal cell body
peroxisomal membrane
Keywords:
ATP-binding
Alport syndrome
Alternative splicing
Complete proteome
Deafness
Disease mutation
Elliptocytosis
Endoplasmic reticulum
Fatty acid metabolism
Hereditary hemolytic anemia
Ligase
Lipid metabolism
Magnesium
Membrane
Mental retardation
Microsome
Mitochondrion
Mitochondrion outer membrane
Nucleotide-binding
Peroxisome
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9598324 9480748 14702039 15489334 18669648 21269460 25944712 11889465 16959974