Names & Taxonomy
- Uniprot ID:
- O60337
- Entry Name:
- MARH6_HUMAN
- Status:
- reviewed
- Protein Names:
- E3 ubiquitin-protein ligase MARCH6 (EC 6.3.2.-) (Doa10 homolog) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (Protein TEB-4) (RING finger protein 176)
- Gene Names:
- MARCH6 KIAA0597 RNF176 TEB4
- Gene Names Primary:
- 42435
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 910
- Sequence:
- MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
- Pathway:
- Protein modification; protein ubiquitination.
- Gene Ontology Go:
- ER ubiquitin ligase complex
integral component of endoplasmic reticulum membrane
integral component of membrane
membrane
enzyme binding
ligase activity
ubiquitin conjugating enzyme binding
ubiquitin protein ligase activity involved in ERAD pathway
ubiquitin-protein transferase activity
ubiquitin-specific protease binding
zinc ion binding
ERAD pathway
proteasomal protein catabolic process
protein K48-linked ubiquitination - Gene Ontology Biological Process:
- ERAD pathway
proteasomal protein catabolic process
protein K48-linked ubiquitination - Gene Ontology Molecular Function:
- enzyme binding
ligase activity
ubiquitin conjugating enzyme binding
ubiquitin protein ligase activity involved in ERAD pathway
ubiquitin-protein transferase activity
ubiquitin-specific protease binding
zinc ion binding - Gene Ontology Cellular Component:
- ER ubiquitin ligase complex
integral component of endoplasmic reticulum membrane
integral component of membrane
membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Endoplasmic reticulum
Ligase
Membrane
Metal-binding
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Ubl conjugation
Ubl conjugation pathway
Zinc
Zinc-finger