Names & Taxonomy
- Uniprot ID:
- O60266
- Entry Name:
- ADCY3_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)
- Gene Names:
- ADCY3 KIAA0511
- Gene Names Primary:
- ADCY3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1144
- Sequence:
- MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
- Catalytic Activity:
- ATP = 3',5'-cyclic AMP + diphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by forskolin. After forskolin treatment, activity is further increased by calcium/calmodulin. In the absence of forskolin, calcium/calmodulin has little effect on enzyme activity.
- Gene Ontology Go:
- cilium
cytoplasm
Golgi apparatus
integral component of membrane
integral component of plasma membrane
membrane
membrane raft
nucleus
plasma membrane
adenylate cyclase activity
ATP binding
calcium- and calmodulin-responsive adenylate cyclase activity
metal ion binding
acrosome reaction
activation of phospholipase C activity
activation of protein kinase A activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cAMP biosynthetic process
cAMP-mediated signaling
cellular response to forskolin
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
female meiotic division
fibroblast growth factor receptor signaling pathway
innate immune response
neurotrophin TRK receptor signaling pathway
olfactory learning
renal water homeostasis
sensory perception of smell
signal transduction
single fertilization
small molecule metabolic process
sperm motility
synaptic transmission
transmembrane transport
water transport - Gene Ontology Biological Process:
- acrosome reaction
activation of phospholipase C activity
activation of protein kinase A activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cAMP biosynthetic process
cAMP-mediated signaling
cellular response to forskolin
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
female meiotic division
fibroblast growth factor receptor signaling pathway
innate immune response
neurotrophin TRK receptor signaling pathway
olfactory learning
renal water homeostasis
sensory perception of smell
signal transduction
single fertilization
small molecule metabolic process
sperm motility
synaptic transmission
transmembrane transport
water transport - Gene Ontology Molecular Function:
- adenylate cyclase activity
ATP binding
calcium- and calmodulin-responsive adenylate cyclase activity
metal ion binding - Gene Ontology Cellular Component:
- cilium
cytoplasm
Golgi apparatus
integral component of membrane
integral component of plasma membrane
membrane
membrane raft
nucleus
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Calmodulin-binding
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Glycoprotein
Golgi apparatus
Isopeptide bond
Lyase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Olfaction
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Sensory transduction
Transmembrane
Transmembrane helix
Ubl conjugation
cAMP biosynthesis