Names & Taxonomy

Uniprot ID:
O43741
Entry Name:
AAKB2_HUMAN
Status:
reviewed
Protein Names:
5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)
Gene Names:
PRKAB2
Gene Names Primary:
PRKAB2
Organism:
Homo sapiens (Human)

Structure

Length:
272
Sequence:
MGNTTSDRVSGERHGAKAARSEGAGGHAPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVSWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYAFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVTTLLYKPI
Proteomes:
UP000005640

Function

Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Cross Reference Drug Bank:
DB00945 DB00131
Gene Ontology Go:
cAMP-dependent protein kinase complex
cytosol
nucleoplasm
nucleotide-activated protein kinase complex
identical protein binding
carnitine shuttle
cell cycle arrest
cellular lipid metabolic process
energy reserve metabolic process
fatty acid biosynthetic process
gene expression
insulin receptor signaling pathway
macroautophagy
membrane organization
mitochondrion organization
organelle organization
protein phosphorylation
regulation of fatty acid biosynthetic process
regulation of protein kinase activity
signal transduction
small molecule metabolic process
transcription initiation from RNA polymerase II promoter
Gene Ontology Biological Process:
carnitine shuttle
cell cycle arrest
cellular lipid metabolic process
energy reserve metabolic process
fatty acid biosynthetic process
gene expression
insulin receptor signaling pathway
macroautophagy
membrane organization
mitochondrion organization
organelle organization
protein phosphorylation
regulation of fatty acid biosynthetic process
regulation of protein kinase activity
signal transduction
small molecule metabolic process
transcription initiation from RNA polymerase II promoter
Gene Ontology Molecular Function:
identical protein binding
Gene Ontology Cellular Component:
cAMP-dependent protein kinase complex
cytosol
nucleoplasm
nucleotide-activated protein kinase complex
Keywords:
3D-structure
Alternative splicing
Complete proteome
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Phosphoprotein
Reference proteome
Interacts With:
Itself; Q8N9N5; Q7L4P6; Q9H2G9; Q8IYA8; O14627; Q96BA8; O43186; P14920; Q5VWN6-2; P15976; Q8WXI9; Q7L5D6; Q08379; Q13422; Q9UKT9; Q9UIH9; Q6A162; P60370; P60409; P60410; P60411; Q9BQ66; Q9BYR5; P26371; Q9BYQ4; Q9BYQ2; Q9BRK4; Q9Y5V3; Q99750; A4D127; O75928; Q13131; P54646; P54619; P61289; P11217; Q8TAI7; Q9UFD9; O43597; O75558; Q8N4C7; Q12933; Q5T124

Publication

PubMed ID:
9575201 12490143 14702039 16710414 15489334 18691976 18669648 18318008 19413330 19369195 19690332 20068231 21460634 17307971 17712357 21269460 21406692 24275569 17851531 21399626