Names & Taxonomy
- Uniprot ID:
- O43613
- Entry Name:
- OX1R_HUMAN
- Status:
- reviewed
- Protein Names:
- Orexin receptor type 1 (Ox-1-R) (Ox1-R) (Ox1R) (Hypocretin receptor type 1)
- Gene Names:
- HCRTR1
- Gene Names Primary:
- HCRTR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 425
- Sequence:
- MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
- Cross Reference Drug Bank:
- DB09034
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
neuropeptide receptor activity
orexin receptor activity
peptide binding
peptide hormone binding
cellular response to hormone stimulus
feeding behavior
neuropeptide signaling pathway
regulation of circadian sleep/wake cycle, sleep
response to peptide
synaptic transmission - Gene Ontology Biological Process:
- cellular response to hormone stimulus
feeding behavior
neuropeptide signaling pathway
regulation of circadian sleep/wake cycle, sleep
response to peptide
synaptic transmission - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
neuropeptide receptor activity
orexin receptor activity
peptide binding
peptide hormone binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix