Names & Taxonomy

Uniprot ID:
O43612
Entry Name:
OREX_HUMAN
Status:
reviewed
Protein Names:
Orexin (Hypocretin) (Hcrt) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)]
Gene Names:
HCRT OX PPORX PPOX
Gene Names Primary:
HCRT
Organism:
Homo sapiens (Human)

Structure

Length:
131
Sequence:
MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAAASVAPGGQSGI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Rough endoplasmic reticulum

Function

Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Gene Ontology Go:
cell junction
cytosol
extracellular region
perinuclear region of cytoplasm
postsynapse
rough endoplasmic reticulum
secretory granule
synaptic vesicle
eating behavior
excitatory postsynaptic potential
negative regulation of DNA replication
negative regulation of potassium ion transport
negative regulation of transmission of nerve impulse
neuropeptide signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of calcium ion transport
positive regulation of cytosolic calcium ion concentration
positive regulation of transmission of nerve impulse
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of neurotransmitter secretion
synaptic transmission
Gene Ontology Biological Process:
eating behavior
excitatory postsynaptic potential
negative regulation of DNA replication
negative regulation of potassium ion transport
negative regulation of transmission of nerve impulse
neuropeptide signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of calcium ion transport
positive regulation of cytosolic calcium ion concentration
positive regulation of transmission of nerve impulse
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of neurotransmitter secretion
synaptic transmission
Gene Ontology Cellular Component:
cell junction
cytosol
extracellular region
perinuclear region of cytoplasm
postsynapse
rough endoplasmic reticulum
secretory granule
synaptic vesicle
Keywords:
3D-structure
Amidation
Cell junction
Cleavage on pair of basic residues
Complete proteome
Cytoplasmic vesicle
Disease mutation
Disulfide bond
Endoplasmic reticulum
Neuropeptide
Pyrrolidone carboxylic acid
Reference proteome
Signal
Synapse

Publication

PubMed ID:
9491897 10364220 10583376 11340621 11283317 15479620 14769912 16429482 10973318