Names & Taxonomy
- Uniprot ID:
- O43525
- Entry Name:
- KCNQ3_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3)
- Gene Names:
- KCNQ3
- Gene Names Primary:
- KCNQ3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 872
- Sequence:
- MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 304 324 Pore-forming; Name=Segment H5.
Function
- Function:
- Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
- Cross Reference Drug Bank:
- DB00321 DB00586 DB04953 DB00939
- Gene Ontology Go:
- axon initial segment
cell surface
node of Ranvier
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
potassium channel activity
voltage-gated potassium channel activity
axon guidance
membrane hyperpolarization
potassium ion transport
synaptic transmission - Gene Ontology Biological Process:
- axon guidance
membrane hyperpolarization
potassium ion transport
synaptic transmission - Gene Ontology Molecular Function:
- delayed rectifier potassium channel activity
potassium channel activity
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- axon initial segment
cell surface
node of Ranvier
plasma membrane
voltage-gated potassium channel complex - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Epilepsy
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel