Names & Taxonomy
- Uniprot ID:
- O43447
- Entry Name:
- PPIH_HUMAN
- Status:
- reviewed
- Protein Names:
- Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP)
- Gene Names:
- PPIH CYP20 CYPH
- Gene Names Primary:
- PPIH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 177
- Sequence:
- MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus speckle
Function
- Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.
- Catalytic Activity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by cyclosporin A.
- Cross Reference Drug Bank:
- DB00172
- Gene Ontology Go:
- cytoplasm
nuclear speck
nucleoplasm
spliceosomal complex
U4/U6 snRNP
U4/U6 x U5 tri-snRNP complex
cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
ribonucleoprotein complex binding
gene expression
mRNA splicing, via spliceosome
positive regulation of viral genome replication
protein complex assembly
protein folding
RNA splicing - Gene Ontology Biological Process:
- gene expression
mRNA splicing, via spliceosome
positive regulation of viral genome replication
protein complex assembly
protein folding
RNA splicing - Gene Ontology Molecular Function:
- cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
ribonucleoprotein complex binding - Gene Ontology Cellular Component:
- cytoplasm
nuclear speck
nucleoplasm
spliceosomal complex
U4/U6 snRNP
U4/U6 x U5 tri-snRNP complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Isomerase
Nucleus
Reference proteome
Rotamase
Spliceosome
mRNA processing
mRNA splicing - Interacts With:
- Q92802; O43172