Names & Taxonomy

Uniprot ID:
O43447
Entry Name:
PPIH_HUMAN
Status:
reviewed
Protein Names:
Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP)
Gene Names:
PPIH CYP20 CYPH
Gene Names Primary:
PPIH
Organism:
Homo sapiens (Human)

Structure

Length:
177
Sequence:
MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus speckle

Function

Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.
Catalytic Activity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme Regulation:
ENZYME REGULATION: Inhibited by cyclosporin A.
Cross Reference Drug Bank:
DB00172
Gene Ontology Go:
cytoplasm
nuclear speck
nucleoplasm
spliceosomal complex
U4/U6 snRNP
U4/U6 x U5 tri-snRNP complex
cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
ribonucleoprotein complex binding
gene expression
mRNA splicing, via spliceosome
positive regulation of viral genome replication
protein complex assembly
protein folding
RNA splicing
Gene Ontology Biological Process:
gene expression
mRNA splicing, via spliceosome
positive regulation of viral genome replication
protein complex assembly
protein folding
RNA splicing
Gene Ontology Molecular Function:
cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
ribonucleoprotein complex binding
Gene Ontology Cellular Component:
cytoplasm
nuclear speck
nucleoplasm
spliceosomal complex
U4/U6 snRNP
U4/U6 x U5 tri-snRNP complex
Keywords:
3D-structure
Acetylation
Alternative splicing
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Isomerase
Nucleus
Reference proteome
Rotamase
Spliceosome
mRNA processing
mRNA splicing
Interacts With:
Q92802; O43172

Publication

PubMed ID:
9404889 9570313 14702039 16710414 15489334 11823439 16723661 21269460 22814378 25944712 10713041 12875835