Names & Taxonomy
- Uniprot ID:
- O43347
- Entry Name:
- MSI1H_HUMAN
- Status:
- reviewed
- Protein Names:
- RNA-binding protein Musashi homolog 1 (Musashi-1)
- Gene Names:
- MSI1
- Gene Names Primary:
- MSI1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 362
- Sequence:
- METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNGYH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
- Gene Ontology Go:
- cytoplasm
nucleus
polysome
nucleotide binding
poly(A) RNA binding
poly(U) RNA binding
RNA binding
nervous system development - Gene Ontology Biological Process:
- nervous system development
- Gene Ontology Molecular Function:
- nucleotide binding
poly(A) RNA binding
poly(U) RNA binding
RNA binding - Gene Ontology Cellular Component:
- cytoplasm
nucleus
polysome - Keywords:
- Acetylation
Complete proteome
Cytoplasm
Nucleus
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Repeat