Names & Taxonomy
- Uniprot ID:
- O43306
- Entry Name:
- ADCY6_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase)
- Gene Names:
- ADCY6 KIAA0422
- Gene Names Primary:
- ADCY6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1168
- Sequence:
- MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity).
- Catalytic Activity:
- ATP = 3',5'-cyclic AMP + diphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by forskolin (PubMed:17916776, PubMed:17110384). Inhibited by calcium ions, already at micromolar concentrations (By similarity). Inhibited by adenosine, AMP and their analogs (By similarity). Activated by GNAS (PubMed:17110384). Is further activated by the complex formed by GNB1 and GNG2 (PubMed:17110384). Phosphorylation by RAF1 results in its activation (By similarity).
- Gene Ontology Go:
- cilium
endosome
integral component of membrane
intrinsic component of plasma membrane
membrane
membrane raft
microvillus membrane
plasma membrane
sarcolemma
adenylate cyclase activity
ATP binding
calcium- and calmodulin-responsive adenylate cyclase activity
metal ion binding
protein kinase binding
activation of phospholipase C activity
activation of protein kinase A activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cAMP biosynthetic process
cAMP-mediated signaling
cellular response to catecholamine stimulus
cellular response to forskolin
cellular response to glucagon stimulus
cellular response to prostaglandin E stimulus
cellular response to vasopressin
dopamine receptor signaling pathway
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
negative regulation of neuron projection development
negative regulation of urine volume
neurotrophin TRK receptor signaling pathway
regulation of vasodilation
renal water homeostasis
signal transduction
small molecule metabolic process
synaptic transmission
transmembrane transport
water transport - Gene Ontology Biological Process:
- activation of phospholipase C activity
activation of protein kinase A activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cAMP biosynthetic process
cAMP-mediated signaling
cellular response to catecholamine stimulus
cellular response to forskolin
cellular response to glucagon stimulus
cellular response to prostaglandin E stimulus
cellular response to vasopressin
dopamine receptor signaling pathway
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
negative regulation of neuron projection development
negative regulation of urine volume
neurotrophin TRK receptor signaling pathway
regulation of vasodilation
renal water homeostasis
signal transduction
small molecule metabolic process
synaptic transmission
transmembrane transport
water transport - Gene Ontology Molecular Function:
- adenylate cyclase activity
ATP binding
calcium- and calmodulin-responsive adenylate cyclase activity
metal ion binding
protein kinase binding - Gene Ontology Cellular Component:
- cilium
endosome
integral component of membrane
intrinsic component of plasma membrane
membrane
membrane raft
microvillus membrane
plasma membrane
sarcolemma - Keywords:
- ATP-binding
Alternative splicing
Cell membrane
Cell projection
Cilium
Complete proteome
Disease mutation
Glycoprotein
Lyase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
cAMP biosynthesis