Names & Taxonomy

Uniprot ID:
O43200
Entry Name:
O43200_HUMAN
Status:
unreviewed
Protein Names:
Thyrotropin receptor (Fragment)
Gene Names:
TSHR
Gene Names Primary:
TSHR
Organism:
Homo sapiens (Human)

Structure

Length:
470
Sequence:
ILESLMCNESSIETLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Gene Ontology Go:
integral component of membrane
plasma membrane
thyroid-stimulating hormone receptor activity
Gene Ontology Molecular Function:
thyroid-stimulating hormone receptor activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
Cell membrane
G-protein coupled receptor
Membrane
Receptor
Transducer
Transmembrane
Transmembrane helix