Names & Taxonomy

Uniprot ID:
O15554
Entry Name:
KCNN4_HUMAN
Status:
reviewed
Protein Names:
Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel)
Gene Names:
KCNN4 IK1 IKCA1 KCA4 SK4
Gene Names Primary:
KCNN4
Organism:
Homo sapiens (Human)

Structure

Length:
427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane
Intramembrane:
INTRAMEM 241 261 Pore-forming; Name=Segment H5.

Function

Function:
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).
Cross Reference Drug Bank:
DB00257 DB00228 DB01159 DB01110 DB00721 DB00468
Gene Ontology Go:
apical plasma membrane
basolateral plasma membrane
membrane raft
neuronal cell body
plasma membrane
voltage-gated potassium channel complex
calcium-activated potassium channel activity
Intermediate conductance calcium-activated potassium channel activity
protein phosphatase binding
small conductance calcium-activated potassium channel activity
calcium ion transport
cell volume homeostasis
defense response
immune system process
phospholipid translocation
positive regulation of protein secretion
positive regulation of T cell receptor signaling pathway
potassium ion export
potassium ion transport
saliva secretion
stabilization of membrane potential
synaptic transmission
Gene Ontology Biological Process:
calcium ion transport
cell volume homeostasis
defense response
immune system process
phospholipid translocation
positive regulation of protein secretion
positive regulation of T cell receptor signaling pathway
potassium ion export
potassium ion transport
saliva secretion
stabilization of membrane potential
synaptic transmission
Gene Ontology Molecular Function:
calcium-activated potassium channel activity
Intermediate conductance calcium-activated potassium channel activity
protein phosphatase binding
small conductance calcium-activated potassium channel activity
Gene Ontology Cellular Component:
apical plasma membrane
basolateral plasma membrane
membrane raft
neuronal cell body
plasma membrane
voltage-gated potassium channel complex
Keywords:
Calmodulin-binding
Cell membrane
Complete proteome
Disease mutation
Hereditary hemolytic anemia
Immunity
Ion channel
Ion transport
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9380751 9326665 9407042 9693050 10961988 15489334 10026195 11425865 15831468 17157250 18796614 22814378 26178367 26148990 26198474