Names & Taxonomy

Uniprot ID:
O15403
Entry Name:
MOT7_HUMAN
Status:
reviewed
Protein Names:
Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6)
Gene Names:
SLC16A6 MCT6 MCT7
Gene Names Primary:
SLC16A6
Organism:
Homo sapiens (Human)

Structure

Length:
523
Sequence:
MTQNKLKLCSKANVYTEVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFIRGPASPKIVIQENRKEAQYMLENEKTRTSIDSIDSGVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKMGLCQHHHSGETKVVSHRGKTLQDIPEDFLEMDLAKNEHRVHVQMEPV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Cross Reference Drug Bank:
DB00119
Gene Ontology Go:
integral component of plasma membrane
membrane
lactate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
symporter activity
monocarboxylic acid transport
plasma membrane lactate transport
Gene Ontology Biological Process:
monocarboxylic acid transport
plasma membrane lactate transport
Gene Ontology Molecular Function:
lactate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
symporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
membrane
Keywords:
Cell membrane
Complete proteome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9425115 15489334 17081983 18691976 18669648