Names & Taxonomy

Uniprot ID:
O15384
Entry Name:
O15384_HUMAN
Status:
unreviewed
Protein Names:
Isocitrate dehydrogenase [NAD] subunit, mitochondrial (EC 1.1.1.41) (Fragment)
Organism:
Homo sapiens (Human)

Structure

Length:
296
Sequence:
DFEEVHVSSNADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHWKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENVRFPSHPTLLPRPVSPCSLL

Subcellular location

Subcellular Location:
Mitochondrion

Function

Catalytic Activity:
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Gene Ontology Go:
mitochondrion
isocitrate dehydrogenase (NAD+) activity
magnesium ion binding
NAD binding
tricarboxylic acid cycle
Gene Ontology Biological Process:
tricarboxylic acid cycle
Gene Ontology Molecular Function:
isocitrate dehydrogenase (NAD+) activity
magnesium ion binding
NAD binding
Gene Ontology Cellular Component:
mitochondrion
Keywords:
Magnesium
Manganese
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Transit peptide
Tricarboxylic acid cycle

Publication

PubMed ID:
9286695