Names & Taxonomy

Uniprot ID:
O15379
Entry Name:
HDAC3_HUMAN
Status:
reviewed
Protein Names:
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (RPD3-2) (SMAP45)
Gene Names:
HDAC3
Gene Names Primary:
HDAC3
Organism:
Homo sapiens (Human)

Structure

Length:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Catalytic Activity:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Active Site:
ACT_SITE 135 135
Cross Reference Drug Bank:
DB06603 DB02546
Gene Ontology Go:
cytoplasm
cytosol
Golgi apparatus
histone deacetylase complex
nucleoplasm
nucleus
plasma membrane
spindle microtubule
transcriptional repressor complex
chromatin binding
cyclin binding
enzyme binding
histone deacetylase activity
histone deacetylase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
NF-kappaB binding
protein deacetylase activity
transcription corepressor activity
transcription factor binding
cellular lipid metabolic process
cellular response to fluid shear stress
chromatin modification
chromatin organization
circadian rhythm
negative regulation of apoptotic process
negative regulation of cell cycle
negative regulation of JNK cascade
negative regulation of nucleic acid-templated transcription
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
positive regulation of protein phosphorylation
positive regulation of TOR signaling
positive regulation of transcription factor import into nucleus
positive regulation of transcription from RNA polymerase II promoter
protein deacetylation
regulation of protein stability
small molecule metabolic process
spindle assembly
transcription, DNA-templated
Gene Ontology Biological Process:
cellular lipid metabolic process
cellular response to fluid shear stress
chromatin modification
chromatin organization
circadian rhythm
negative regulation of apoptotic process
negative regulation of cell cycle
negative regulation of JNK cascade
negative regulation of nucleic acid-templated transcription
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
neurotrophin TRK receptor signaling pathway
Notch signaling pathway
positive regulation of protein phosphorylation
positive regulation of TOR signaling
positive regulation of transcription factor import into nucleus
positive regulation of transcription from RNA polymerase II promoter
protein deacetylation
regulation of protein stability
small molecule metabolic process
spindle assembly
transcription, DNA-templated
Gene Ontology Molecular Function:
chromatin binding
cyclin binding
enzyme binding
histone deacetylase activity
histone deacetylase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
NF-kappaB binding
protein deacetylase activity
transcription corepressor activity
transcription factor binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
Golgi apparatus
histone deacetylase complex
nucleoplasm
nucleus
plasma membrane
spindle microtubule
transcriptional repressor complex
Keywords:
3D-structure
Alternative splicing
Chromatin regulator
Complete proteome
Cytoplasm
Hydrolase
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Interacts With:
Q9UKG1; Q7L2E3; P08393; O60341; Q969R5; P43356; Q9UIS9; P01106; O75376; Q9Y5X4; P48552; Q8CBD1; P60510; Q15022; P12504

Publication

PubMed ID:
9464271 9346952 9501169 10051405 15489334 11006275 10669754 10655483 10860984 11466315 11533236 11861901 12032081 10809664 10944117 10898795 11931768 12628926 14633989 14525983 15297880 15927959 16569215 17081983 18417529 18655026 19409814 19690332 21030595 21269460 21914818 21444723 23911289 25190803