Names & Taxonomy
- Uniprot ID:
- O15145
- Entry Name:
- ARPC3_HUMAN
- Status:
- reviewed
- Protein Names:
- Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
- Gene Names:
- ARPC3 ARC21
- Gene Names Primary:
- ARPC3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 178
- Sequence:
- MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton. Cell projection.
Function
- Function:
- Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
- Gene Ontology Go:
- actin cytoskeleton
Arp2/3 protein complex
cytosol
extracellular exosome
focal adhesion
lamellipodium
membrane
structural constituent of cytoskeleton
Arp2/3 complex-mediated actin nucleation
axon guidance
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
movement of cell or subcellular component
small GTPase mediated signal transduction - Gene Ontology Biological Process:
- Arp2/3 complex-mediated actin nucleation
axon guidance
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
movement of cell or subcellular component
small GTPase mediated signal transduction - Gene Ontology Molecular Function:
- structural constituent of cytoskeleton
- Gene Ontology Cellular Component:
- actin cytoskeleton
Arp2/3 protein complex
cytosol
extracellular exosome
focal adhesion
lamellipodium
membrane - Keywords:
- Acetylation
Actin-binding
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Phosphoprotein
Reference proteome - Interacts With:
- Q08379; O43365; P48552; O00401