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Names & Taxonomy

Uniprot ID:: O14965
Entry Name:: AURKA_HUMAN
Status:: reviewed
Protein Names:: Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
Gene Names:: AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6
Gene Names Primary:: AURKA
Organism:: Homo sapiens (Human)

Structure

Length:: 403
Sequence:: MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Function

Function:: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Catalytic Activity:: ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation:: ENZYME REGULATION: Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO.
Active Site:: ACT_SITE 256 256 Proton acceptor.
Gene Ontology Go:: axon hillock
centriole
centrosome
chromosome passenger complex
cilium
condensed nuclear chromosome, centromeric region
cytosol
germinal vesicle
meiotic spindle
microtubule
microtubule cytoskeleton
midbody
mitotic spindle
nucleus
perinuclear region of cytoplasm
pronucleus
spindle
spindle midzone
spindle pole centrosome
ATP binding
histone serine kinase activity
protein kinase activity
protein kinase binding
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
anterior/posterior axis specification
cell division
cellular protein metabolic process
centrosome localization
G2/M transition of mitotic cell cycle
mitotic cell cycle
mitotic centrosome separation
mitotic nuclear division
mitotic spindle organization
negative regulation of apoptotic process
negative regulation of protein binding
neuron projection extension
positive regulation of mitotic nuclear division
positive regulation of oocyte maturation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
post-translational protein modification
protein autophosphorylation
protein localization to centrosome
protein phosphorylation
protein sumoylation
regulation of centrosome cycle
regulation of cytokinesis
regulation of protein stability
response to estradiol
spindle assembly involved in female meiosis I
spindle stabilization
Gene Ontology Biological Process:: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
anterior/posterior axis specification
cell division
cellular protein metabolic process
centrosome localization
G2/M transition of mitotic cell cycle
mitotic cell cycle
mitotic centrosome separation
mitotic nuclear division
mitotic spindle organization
negative regulation of apoptotic process
negative regulation of protein binding
neuron projection extension
positive regulation of mitotic nuclear division
positive regulation of oocyte maturation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
post-translational protein modification
protein autophosphorylation
protein localization to centrosome
protein phosphorylation
protein sumoylation
regulation of centrosome cycle
regulation of cytokinesis
regulation of protein stability
response to estradiol
spindle assembly involved in female meiosis I
spindle stabilization
Gene Ontology Molecular Function:: ATP binding
histone serine kinase activity
protein kinase activity
protein kinase binding
protein serine/threonine/tyrosine kinase activity
protein serine/threonine kinase activity
Gene Ontology Cellular Component:: axon hillock
centriole
centrosome
chromosome passenger complex
cilium
condensed nuclear chromosome, centromeric region
cytosol
germinal vesicle
meiotic spindle
microtubule
microtubule cytoskeleton
midbody
mitotic spindle
nucleus
perinuclear region of cytoplasm
pronucleus
spindle
spindle midzone
spindle pole centrosome
Keywords:: 3D-structure
ATP-binding
Cell cycle
Cell division
Cell projection
Cilium
Cilium biogenesis/degradation
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Microtubule
Mitosis
Nucleotide-binding
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
Serine/threonine-protein kinase
Transferase
Ubl conjugation
Interacts With:: Q9NWT8; P00533; P61978; Q13123; P04198; P06748; Q8VDQ8; O15350; Q9ULW0

Names & Taxonomy

Structure

Subcellular location

Function

Publication