Names & Taxonomy
- Uniprot ID:
- O14880
- Entry Name:
- MGST3_HUMAN
- Status:
- reviewed
- Protein Names:
- Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) (Microsomal GST-III)
- Gene Names:
- MGST3
- Gene Names Primary:
- MGST3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 152
- Sequence:
- MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSIALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Also functions as a glutathione peroxidase.
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane
glutathione peroxidase activity
glutathione transferase activity
peroxidase activity
cellular oxidant detoxification
glutathione derivative biosynthetic process
lipid metabolic process
response to organonitrogen compound
signal transduction
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular oxidant detoxification
glutathione derivative biosynthetic process
lipid metabolic process
response to organonitrogen compound
signal transduction
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glutathione peroxidase activity
glutathione transferase activity
peroxidase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
intracellular membrane-bounded organelle
membrane - Keywords:
- Complete proteome
Endoplasmic reticulum
Lipoprotein
Membrane
Microsome
Palmitate
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix - Interacts With:
- P24863