Names & Taxonomy
- Uniprot ID:
- O14756
- Entry Name:
- H17B6_HUMAN
- Status:
- reviewed
- Protein Names:
- 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6)
- Gene Names:
- HSD17B6 RODH SDR9C6
- Gene Names Primary:
- HSD17B6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 317
- Sequence:
- MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTRSWPKPAQAV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome membrane
Function
- Function:
- NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
- Catalytic Activity:
- 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.; Testosterone + NAD(+) = androstenedione + NADH.; All-trans-retinol- + NAD(+) = all-trans-retinal- + NADH.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=0.19 uM for NAD
- Active Site:
- ACT_SITE 176 176 Proton acceptor.
- Cross Reference Drug Bank:
- DB00139
- Gene Ontology Go:
- early endosome membrane
endoplasmic reticulum
intracellular
catalytic activity
electron carrier activity
estradiol 17-beta-dehydrogenase activity
oxidoreductase activity
retinol dehydrogenase activity
testosterone dehydrogenase (NAD+) activity
androgen biosynthetic process
androgen catabolic process - Gene Ontology Biological Process:
- androgen biosynthetic process
androgen catabolic process - Gene Ontology Molecular Function:
- catalytic activity
electron carrier activity
estradiol 17-beta-dehydrogenase activity
oxidoreductase activity
retinol dehydrogenase activity
testosterone dehydrogenase (NAD+) activity - Gene Ontology Cellular Component:
- early endosome membrane
endoplasmic reticulum
intracellular - Keywords:
- Complete proteome
Endoplasmic reticulum
Endosome
Glycoprotein
Lipid metabolism
Membrane
Microsome
NAD
Oxidoreductase
Reference proteome
Signal
Steroid metabolism