Names & Taxonomy

Uniprot ID:
O14735
Entry Name:
CDIPT_HUMAN
Status:
reviewed
Protein Names:
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)
Gene Names:
CDIPT PIS PIS1
Gene Names Primary:
CDIPT
Organism:
Homo sapiens (Human)

Structure

Length:
213
Sequence:
MPDENIFLFVPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTAPIALLKSLISVIHLITAARNMAALDAADRAKKK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.
Catalytic Activity:
CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.
Cofactor:
COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Enzyme Regulation:
ENZYME REGULATION: Inhibited by PtdIns (product inhibition), phosphatidylinositol phosphate, and nucleoside di- and tri-phosphates.
Gene Ontology Go:
endoplasmic reticulum membrane
Golgi apparatus
Golgi membrane
integral component of membrane
membrane
plasma membrane
alcohol binding
carbohydrate binding
CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
diacylglycerol binding
manganese ion binding
CDP-diacylglycerol metabolic process
glycerophospholipid biosynthetic process
phosphatidylinositol biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
CDP-diacylglycerol metabolic process
glycerophospholipid biosynthetic process
phosphatidylinositol biosynthetic process
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
alcohol binding
carbohydrate binding
CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
diacylglycerol binding
manganese ion binding
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
Golgi apparatus
Golgi membrane
integral component of membrane
membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Lipid biosynthesis
Lipid metabolism
Magnesium
Manganese
Membrane
Phospholipid biosynthesis
Phospholipid metabolism
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix
Interacts With:
O95197; O00560

Publication

PubMed ID:
9407135 14702039 15616553 15489334 8110188 21269460